Table 3
Summary of studies on Hypericum Vs Placebo
| Authors year | No | substance | dose | Hamilton start end |
Other start end |
Resp rate | Stat. sign. | Side eff. | Weeks | drop outs | Inclusion criteria |
| Witte 1995 |
48 49 |
Psychotonin Placebo |
0,5 mg x2 | 24.6 7.9 23 12 |
25 8 21 DS 12 |
79 % 56% |
p< 0.02 |
0 0 |
6 | 21% total |
ICD10 F32.1 |
| Ditzler 1994 | 30 30 |
Nerapas* Placebo |
0,24mgx3* | 15,3 7,3 18,4 DS 12,0 |
55,7 38,4 56,8 DSI 3,9 |
67% 33% |
p< 0,01 | No diff |
8 | 3% 0% |
DSM -III-R, major depression, |
| Sommer 1993 |
42 47 |
Jarsin 300 Placebo |
0,9 mg x 3 | 15.8 7.2 15.8 11,.3 |
_ | 67% 28% |
p< 0.01 |
No diff |
4 | 4% 14% |
ICD 09 300.4 309.0 |
| Hubner 1993 |
20 19 |
Jarsin 300 Placebo |
0,9 mg x 3 | 12.5 5 12.4 11 |
15.8 6.8 16.7 HS 16.9 |
70% 47% |
p< 0.05 |
No diff | 4 | _ | ICD 09 300.4 309.0 |
| König 1993 | 55 57 |
extr. Z 90017 Placebo |
0,5-1 mgx2 | 34,7 20,8 34,3 B-S 21,1 |
64,1 48,2 64,7 DSI 50,6 |
53% 53% |
no diff | 22% 28% |
6 | 24% 26% |
Psychoaff. disorders with depressed mood |
| Hänsgen 1993 |
33 34 |
Jarsin 300 Placebo |
0,9 mg x 3 | 21.8 6 20.4 14 |
131 77 127 BEB 104 |
81% 26% |
p< 0.001 |
6% 3% |
6 | 3% 12% |
DSM III R major depression |
| Lehrl 1993 | 25 25 |
Jarsin Placebo |
0,37mg x 3 | 23,7 17,4 21,6 16,8 |
39,7 34,5 41,2 KAI 37,7 |
42% 25% |
no diff | 4 | ? ? |
ICD 09 300,4 309,0 | |
| Schmidt 1993 |
32 33 |
Jarsin 300 Placebo |
0.9 mg x 3 | ? ? ? ? |
No cognitive problems | 67% 27% |
p< 0.01 |
7% 10% |
6 | 0% | ICD 09 300,4 309,0 |
| Martinez 1993 |
10 10 |
Jarsin 300 + light therapy |
300 Lux 3000 Lux |
20.6 8.2 21.9 6.1 |
_ | _ | No sign |
0% 0% |
4 | 0% | DSM III R SAD |
| Quandt, 1993 | 88 | Psychotonin Placebo |
0,37mg x3 | 17.8 9.8 17.3 16.6 |
- | 71% 7,7% |
p< 0.001 |
0% 0% |
4 | ? | ICD 09 300.4 |
| Osterheider 1992 | 22 2 |
Psychotonin Placebo |
0,25mg x 3 | ? ? ? ? |
? ? ? ? |
0% 0% |
No diff | ? | 8 | ? | Unspecified Depression |
| Reh, 1992 |
25 25 |
Neuroplant Placebo |
0,5 mg x 2 | 19 8 20 14 |
30 9 32 D-S 22 |
80% 44% |
p< 0,02 | 0% 0% |
8 | 0% 0% |
ICD 09 300.4 309.0 311.0 |
| Harrer 1991 |
58 58 |
Psychotonin Placebo |
0,37mg x 3 | 21,6 8,9 20,9 16,1 |
11,9 4,5 12,1 HAMA 8,2 |
75% 25% |
p< 0,001 |
2% 0% |
6 | 6,4% 1,8% |
ICD 9 304,4 309,9 |
| Halama 1991 |
25 25 |
Jarsin Placebo |
0,37 mg | 18,0 10.0 17,5 18,0 |
30.0 12,5 30,0 B-L 29,5 |
50% 0% |
p< 0,005 |
4 % 0 % |
4 | 0% 0% |
ICD 09 300,4 309,0 |
| Schmidt 1989 |
16 12 |
Psychotonin Placebo |
0,37mgx3 | 29,2 9,7 29,5 19,5 |
64.2 51,9 60,3 STAI 53,1 |
62,% 33,% |
p< 0,01 |
0% 0% |
4 | 0% 0% |
ICD 09 290,2. 296,1 298,0. 300,0 300,4 |
| Schlich 1987 |
22 24 |
Psychotonin Placebo |
0,25mgx3 | 22,9 16,4 24,0 29,6 |
60,9 19,7 61,6 55,3 |
68% 10% |
p< 0,05 |
0% 0% |
4 | 6% total |
Unspecified depression |
| Hoffman 1979 |
30 30 |
Hyperforat Placebo |
0,3mg x 3 | - | 1,76 own 0,68 1,83 scale 1,54 |
61% 16% |
not made |
0% 0% |
6 | 0% 0% |
mild to moderate depression |
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